PSXIII-B-11 Identification of Haplotypes Associated with Fetal Loss in Dairy Cattle

نویسندگان

چکیده

Abstract Fetal loss occurs in 4 to 13% of dairy cattle worldwide with a subsequent $487 $1900 economic per pregnancy. Previous studies have identified SNPs associated fetal loss, but few investigated haplotypes (DNA that segregates offspring together) loss. The objective this study was identify Holstein heifers and cows conceived the first insemination. This consisted 529 (470 maintained pregnancies term while 59 experienced loss) 517 (490 28 suffered loss). Cattle (cases) were genotyped using Neogen BovineGGP50 BeadChip (SNPs = 43,938) calved at (controls) Illumina BovineHD 777,962). Cases imputed HD density BEAGLE (4.1). controls combined 62,819 haplotypes. Haplotype association tests run for three populations (heifers, cows, combined) chi-squared Bonferroni (BF) corrected significance p < 0.05. haplotype analyses 121, 47, 102 heifer, cow populations, respectively. Of these, 37 shared between heifer 39 combined, 76 across all analyses. Loci compared loci (BF 0.05) SNP by genome wide There 22 heifers, 10 21 population. use haplotypes, an additional 150 can be further characterized their value selecting are less prone late abortions.

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ژورنال

عنوان ژورنال: Journal of Animal Science

سال: 2022

ISSN: ['0021-8812', '1525-3163', '1525-3015', '1544-7847']

DOI: https://doi.org/10.1093/jas/skac247.591